CNRI founded in 1991, specializes in phase I-IV inpatient and outpatient clinical trials for schizophrenia, bipolar disorder, major depression, among others and has successfully completed over 300 CNS studies. We also have inpatient facilities to conduct phase I and sleep studies in patients and healthy volunteers. We pride ourselves in always exceeding CROs’ and Pharmaceutical Companies’ goals, and in having exceptional documentation per Sponsors’ audit reports. CNRI has 2 locations: 1) San Diego (Investigators: Dr. Tran-Johnson, Dr. Benbow, Dr. Bobo, Dr. Chen - Medical Director, Dr. Olonan, Dr. Takamura, among others); 2) Los Angeles (Investigators: Dr. Manning-Medical Director, Dr. El-Gabalawy, Dr. Jacobs, Dr. Shah, Dr. Alkhouri, among others).
CNRI prides itself on rapid enrollment of appropriate patients with a very good retention rate. We always meet our enrollment goals and in most cases exceed our enrollment by 2 or 3 times with a focus on high quality data. In addition, our site has been recognized by several pharmaceutical companies for having a very good placebo/drug response separation. We have board certified internists in addition to psychiatrists that review and sign all safety data such as labs, ECGs, perform medical/psychiatric evaluations, adverse event monitoring and assessment of adverse event study drug relationship. All patients are evaluated by the PI, psychiatrists, internists, psychologist level raters, nurses, and study coordinators throughout their study participation.
CNRI has been recognized several times in the last 5 years for having good drug/placebo response separation for schizophrenia, bipolar disorder and major depression studies sponsored by Abbott, Alexza, Astra Zeneca, Bristol-Myers Squibb, Corcept, Eli-Lilly, GlaxoSmithKline, Merck, Novartis, Organon, Otsuka, Sanofi-aventis, Sunovion, Takeda, RW Johnson, Janssen LP, Vanda, etc... Dr. Tran- Johnson has also been selected as a Signatory Investigator for several Clinical Study Reports submitted to the FDA and manuscripts for studies completed due to high enrollment, high retention rate, excellent drug/placebo response separation, and excellent data quality. In our FDA audits in April 2006, April 2010, and June 2014, no 483s were issued.
CNRI has over 50 staff members to conduct our clinical trials, including 6 Board Certified Psychiatrists, 6 Board Certified Internists, 1 Board Certified Neurologist, 1 Board Certified Rheumatologist, clinicians with sleep medicine experience, 10 Project Managers/Study Coordinators, Research Nurses, Sleep Technicians, Doctorate level Psychiatric Raters, Transcription/Data Coordinators (some with M.D. training), Patient Recruitment Specialists, Administrators, Regulatory Coordinators, scheduling, transportation, and support staff members.
CNRI has successfully completed over 300 clinical studies for the following sponsors:
Glaxo Smith Kline
Janssen Research Foundation
Johnson & Johnson
Ortho McNeil Janssen
R W Johnson
CNRI has also been fortunate to have worked with the following CROs’ over the years: